The fourth edition of Oxford Handbook of Rheumatology has been fully reviewed and practically structured. There is a comprehensive and updated account of assessment, guidelines, and treatment options. It focuses on presenting symptoms and considers key diseases, emergencies, and rare diseases in detail. It includes new chapters on rare autoinflammatory diseases (RAIDs) and hereditary disorders of connective tissue (HDCT) making this an invaluable guide for the trainee doctors and consultant rheumatologists.